Abstract: For the past 15 years, our research has focused on the evolution of the first Yakut populations, their interaction with local tribes as well as with the Russian population, which marks the beginning of Yakutia's development from the first half of the 17th century. We conducted the excavation of tombs and we analysed the cultural, historical and paleogenetic data uncovered. A review and a synthesis of the main results published in articles and monographs informs our research directions for the future.