Abstract: We investigate the impact of unmodelled 3-D structural heterogeneity on inverted W-phase source parameters. We generate a large data set of synthetic seismograms accounting for the Earths 3-D structure for 250 earthquakes globally distributed. The W-phase algorithm is then used to invert for earthquake CMT parameters, assuming a spherical Earth model. The impact of lateral heterogeneity is assessed by comparing inverted source parameters with those used to compute the 3-D synthetics. Results show that the 3-D structure mainly affects centroid location while the effect on the other source parameters remains small. Centroid mislocations present clear geographical patterns. In particular, W-phase solutions for earthquakes in South America are on average biased 17 km to the east of the actual centroid locations. This effect is significantly reduced using an azimuthally well balanced distribution of seismological stations. Source parameters are generally more impacted by mantle heterogeneity while the scalar moment of shallow earthquakes seems to be mainly impacted by the crustal structure. Shallow earthquakes present a variability of Mrθ and Mrϕ moment tensor elements, resulting both from the small amplitude and a larger uncertainty of the associated Green’s functions.