| |
Records |
Links |
|
Author |
Crubézy E. |
|
| |
Title |
« Les tombes gelées de Sibérie orientale », In : L’archéologie au laboratoire, (La découverte), Thiébault S., Depaepe P.,( dir.) |
Type |
Book Chapter |
| |
Year |
2013 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
49-60 |
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Programme  |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
4695 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Crubézy E., Marty M-T. |
|
| |
Title |
La recherche anthropobiologique en milieu polaire. In : Mondes Polaires. Edts CNRS et Cherche-Midi. Paris. |
Type |
Book Chapter |
| |
Year |
2013 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
152-155 |
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
4699 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Dabernat Henri, Thèves Catherine, Bouakaze Caroline, Nikolaeva Dariya, Keyser Christine, Mokrousov Igor, Géraut Annie, Duchesne Sylvie, Gérard Patrice, Alexeev Anatoly N, Crubézy Eric, Ludes Bertrand, |
|
| |
Title |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century
|
Type |
Journal Article |
| |
Year |
2014 |
Publication |
PLoS ONE |
Abbreviated Journal |
|
|
| |
Volume |
9 |
Issue |
2 |
Pages |
e89877- |
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Public Library of Science |
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1932-6203 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
4900 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Der Sarkissian C, Ermini L, Jónsson H, Alekseev A N, Crubezy E, Shapiro B, Orlando L, |
|
| |
Title |
Shotgun microbial profiling of fossil remains
|
Type |
Journal Article |
| |
Year |
2014 |
Publication |
Molecular Ecology |
Abbreviated Journal |
Mol. Ecol. |
|
| |
Volume |
23 |
Issue |
7 |
Pages |
1780-1798 |
|
| |
Keywords |
ancient DNA, metagenomics, microbial profiling, next-generation sequencing, |
|
| |
Abstract |
Millions to billions of DNA sequences can now be generated from ancient skeletal remains thanks to the massive throughput of next-generation sequencing platforms. Except in cases of exceptional endogenous DNA preservation, most of the sequences isolated from fossil material do not originate from the specimen of interest, but instead reflect environmental organisms that colonized the specimen after death. Here, we characterize the microbial diversity recovered from seven c. 200- to 13 000-year-old horse bones collected from northern Siberia. We use a robust, taxonomy-based assignment approach to identify the microorganisms present in ancient DNA extracts and quantify their relative abundance. Our results suggest that molecular preservation niches exist within ancient samples that can potentially be used to characterize the environments from which the remains are recovered. In addition, microbial community profiling of the seven specimens revealed site-specific environmental signatures. These microbial communities appear to comprise mainly organisms that colonized the fossils recently. Our approach significantly extends the amount of useful data that can be recovered from ancient specimens using a shotgun sequencing approach. In future, it may be possible to correlate, for example, the accumulation of postmortem DNA damage with the presence and/or abundance of particular microbes.
|
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1365-294X |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
4901 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Hollard Clémence, Keyser Christine, Giscard Pierre-Henri, Tsagaan Turbat, Bayarkhuu Noost, Bemmann Jan, Crubézy Eric, Ludes Bertrand, |
|
| |
Title |
Strong genetic admixture in the Altai at the Middle Bronze Age revealed by uniparental and ancestry informative markers
|
Type |
Journal Article |
| |
Year |
2014 |
Publication |
Forensic Science International: Genetics |
Abbreviated Journal |
Forensic Sci Int Genet |
|
| |
Volume |
12 |
Issue |
|
Pages |
199-207 |
|
| |
Keywords |
Ancient DNA, Admixture, Bronze Age, Altai Mountains, |
|
| |
Abstract |
|
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1872-4973 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
4902 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Keyser Christine, Hollard Clémence, Gonzalez Angela, Fausser Jean-Luc, Rivals Eric, Alexeev Anatoly Nikolayevich, Riberon Alexandre, Crubézy Eric, Ludes Bertrand, |
|
| |
Title |
The ancient Yakuts: a population genetic enigma
|
Type |
Journal Article |
| |
Year |
2014 |
Publication |
Philosophical Transactions of the Royal Society of London B: Biological Sciences |
Abbreviated Journal |
Philos. Trans. R. Soc. Lond., B, Biol. Sci. |
|
| |
Volume |
370 |
Issue |
1660 |
Pages |
|
|
| |
Keywords |
|
|
| |
Abstract |
This study is part of an ongoing project aiming at determining the ethnogenesis of an eastern Siberian ethnic group, the Yakuts, on the basis of archaeological excavations carried out over a period of 10 years in three regions of Yakutia: Central Yakutia, the Vilyuy River basin and the Verkhoyansk area. In this study, genetic analyses were carried out on skeletal remains from 130 individuals of unknown ancestry dated mainly from the fifteenth to the nineteenth century AD. Kinship studies were conducted using sets of commercially available autosomal and Y-chromosomal short tandem repeats (STRs) along with hypervariable region I sequences of the mitochondrial DNA. An unexpected and intriguing finding of this work was that the uniparental marker systems did not always corroborate results from autosomal DNA analyses; in some cases, false-positive relationships were observed. These discrepancies revealed that 15 autosomal STR loci are not sufficient to discriminate between first degree relatives and more distantly related individuals in our ancient Yakut sample. The Y-STR analyses led to similar conclusions, because the current Y-STR panels provided the limited resolution of the paternal lineages.
|
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0962-8436 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
4904 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Thèves C, Biagini P, Crubézy E, |
|
| |
Title |
The rediscovery of smallpox
|
Type |
Journal Article |
| |
Year |
2014 |
Publication |
Clinical Microbiology and Infection |
Abbreviated Journal |
Clin. Microbiol. Infect. |
|
| |
Volume |
20 |
Issue |
3 |
Pages |
210-218 |
|
| |
Keywords |
|
|
| |
Abstract |
Smallpox is an infectious disease that is unique to humans, caused by a poxvirus. It is one of the most lethal of diseases; the virus variant Variola major has a mortality rate of 30%. People surviving this disease have life-long consequences, but also assured immunity. Historically, smallpox was recognized early in human populations. This led to prevention attempts?variolation, quarantine, and the isolation of infected subjects?until Jenner?s discovery of the first steps of vaccination in the 18th century. After vaccination campaigns throughout the 19th and 20th centuries, the WHO declared the eradication of smallpox in 1980. With the development of microscopy techniques, the structural characterization of the virus began in the early 20th century. In 1990, the genomes of different smallpox viruses were determined; viruses could be classified in order to investigate their origin, diffusion, and evolution. To study the evolution and possible re-emergence of this viral pathogen, however, researchers can only use viral genomes collected during the 20th century. Cases of smallpox in ancient periods are sometimes well documented, so palaeomicrobiology and, more precisely, the study of ancient smallpox viral strains could be an exceptional opportunity. The analysis of poxvirus fragmented genomes could give new insights into the genetic evolution of the poxvirus. Recently, small fragments of the poxvirus genome were detected. With the genetic information obtained, a new phylogeny of smallpox virus was described. The interest in conducting studies on ancient strains is discussed, in order to explore the natural history of this disease. |
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier |
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1198-743X |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
4905 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Librado Pablo, Der Sarkissian Clio, Ermini Luca, Schubert Mikkel, Jónsson Hákon, Albrechtsen Anders, Fumagalli Matteo, Yang Melinda A, Gamba Cristina, Seguin-Orlando Andaine, Mortensen Cecilie D, Petersen Bent, Hoover Cindi A, Lorente-Galdos Belen, Nedoluzhko Artem, Boulygina Eugenia, Tsygankova Svetlana, Neuditschko Markus, Jagannathan Vidhya, Thèves Catherine, Alfarhan Ahmed H, Alquraishi Saleh A, Al-Rasheid Khaled A S, Sicheritz-Ponten Thomas, Popov Ruslan, Grigoriev Semyon, Alekseev Anatoly N, Rubin Edward M, McCue Molly, Rieder Stefan, Leeb Tosso, Tikhonov Alexei, Crubézy Eric, Slatkin Montgomery, Marques-Bonet Tomas, Nielsen Rasmus, Willerslev Eske, Kantanen Juha, Prokhortchouk Egor, Orlando Ludovic, |
|
| |
Title |
Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments
|
Type |
Journal Article |
| |
Year |
2015 |
Publication |
Proceedings of the National Academy of Sciences |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
|
| |
Volume |
112 |
Issue |
50 |
Pages |
201513696-201513696 |
|
| |
Keywords |
|
|
| |
Abstract |
Yakutia, Sakha Republic, in the Siberian Far East, represents one of the coldest places on Earth, with winter record temperatures dropping below -70 °C. Nevertheless, Yakutian horses survive all year round in the open air due to striking phenotypic adaptations, including compact body conformations, extremely hairy winter coats, and acute seasonal differences in metabolic activities. The evolutionary origins of Yakutian horses and the genetic basis of their adaptations remain, however, contentious. Here, we present the complete genomes of nine present-day Yakutian horses and two ancient specimens dating from the early 19th century and ∼5,200 y ago. By comparing these genomes with the genomes of two Late Pleistocene, 27 domesticated, and three wild Przewalski's horses, we find that contemporary Yakutian horses do not descend from the native horses that populated the region until the mid-Holocene, but were most likely introduced following the migration of the Yakut people a few centuries ago. Thus, they represent one of the fastest cases of adaptation to the extreme temperatures of the Arctic. We find cis-regulatory mutations to have contributed more than nonsynonymous changes to their adaptation, likely due to the comparatively limited standing variation within gene bodies at the time the population was founded. Genes involved in hair development, body size, and metabolic and hormone signaling pathways represent an essential part of the Yakutian horse adaptive genetic toolkit. Finally, we find evidence for convergent evolution with native human populations and woolly mammoths, suggesting that only a few evolutionary strategies are compatible with survival in extremely cold environments. |
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0027-8424 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
6068 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Magnaval Jean-François, Leparc-Goffart Isabelle, Gibert Morgane, Gurieva Alla, Outreville Jonathan, Dyachkovskaya Praskovia, Fabre Richard, Fedorova Sardana, Nikolaeva Dariya, Dubois Damien, Melnitchuk Olga, Daviaud-Fabre Pascale, Marty Marie, Alekseev Anatoly, Crubezy Eric, |
|
| |
Title |
A Serological Survey About Zoonoses in the Verkhoyansk Area, Northeastern Siberia (Sakha Republic, Russian Federation).
|
Type |
Journal Article |
| |
Year |
2016 |
Publication |
Vector borne and zoonotic diseases (Larchmont, N.Y.) |
Abbreviated Journal |
|
|
| |
Volume |
16 |
Issue |
2 |
Pages |
103-9 |
|
| |
Keywords |
Arctic, Seroepidemiology, Verkhoyansk, Yakutia, Zoonoses, |
|
| |
Abstract |
In 2012, a seroprevalence survey concerning 10 zoonoses, which were bacterial (Lyme borreliosis and Q fever), parasitic (alveolar echinococcosis [AE] and cystic echinococcosis [CE], cysticercosis, toxoplasmosis, toxocariasis, and trichinellosis), or arboviral (tick-borne encephalitis and West Nile virus infection), was conducted among 77 adult volunteers inhabiting Suordakh and Tomtor Arctic villages in the Verkhoyansk area (Yakutia). Following serological testing by enzyme-linked immunosorbent assay and/or western blot, no positive result was found for cysticercosis, CE, toxocariasis, trichinellosis, and both arboviral zoonoses. Four subjects (5.2%) had anti-Toxoplasma IgG, without the presence of specific IgM. More importantly, eight subjects (10.4%) tested positive for Lyme borreliosis, two (2.6%) for recently acquired Q fever, and one (1.3%) for AE. Lyme infection and Q fever, whose presence had not been reported so far in Arctic Yakutia, appeared therefore to be a major health threat for people dwelling, sporting, or working in the Arctic area of the Sakha Republic.
|
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0002-9637 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
4207 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Keyser Christine, Hollard Clémence, Gonzalez Angela, Fausser Jean-Luc, Rivals Eric, Alexeev Anatoly Nikolayevich, Riberon Alexandre, Crubézy Eric, Ludes Bertrand, |
|
| |
Title |
The ancient Yakuts: a population genetic enigma.
|
Type |
Journal Article |
| |
Year |
2015 |
Publication |
Philosophical transactions of the Royal Society of London. Series B, Biological sciences |
Abbreviated Journal |
|
|
| |
Volume |
370 |
Issue |
1660 |
Pages |
20130385-20130385 |
|
| |
Keywords |
Base Sequence, Bone and Bones, Bone and Bones: chemistry, Chromosomes, Human, Y, Chromosomes, Human, Y: genetics, DNA, Mitochondrial, DNA, Mitochondrial: genetics, DNA, Mitochondrial: history, Ethnic Groups, Ethnic Groups: genetics, Ethnic Groups: history, Fossils, Genetics, Population, Haplotypes, Haplotypes: genetics, History, 15th Century, History, 16th Century, History, 17th Century, History, 18th Century, History, 19th Century, Humans, Likelihood Functions, Male, Microsatellite Repeats, Microsatellite Repeats: genetics, Molecular Sequence Data, Pedigree, Polymorphism, Single Nucleotide, Polymorphism, Single Nucleotide: genetics, Sequence Analysis, DNA, Siberia, |
|
| |
Abstract |
This study is part of an ongoing project aiming at determining the ethnogenesis of an eastern Siberian ethnic group, the Yakuts, on the basis of archaeological excavations carried out over a period of 10 years in three regions of Yakutia: Central Yakutia, the Vilyuy River basin and the Verkhoyansk area. In this study, genetic analyses were carried out on skeletal remains from 130 individuals of unknown ancestry dated mainly from the fifteenth to the nineteenth century AD. Kinship studies were conducted using sets of commercially available autosomal and Y-chromosomal short tandem repeats (STRs) along with hypervariable region I sequences of the mitochondrial DNA. An unexpected and intriguing finding of this work was that the uniparental marker systems did not always corroborate results from autosomal DNA analyses; in some cases, false-positive relationships were observed. These discrepancies revealed that 15 autosomal STR loci are not sufficient to discriminate between first degree relatives and more distantly related individuals in our ancient Yakut sample. The Y-STR analyses led to similar conclusions, because the current Y-STR panels provided the limited resolution of the paternal lineages.
|
|
| |
Programme |
1038 |
|
| |
Campaign |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1471-2970 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
|
Serial |
6240 |
|
| Permanent link to this record |
